Instrumentation in Clinical Biochemistry

As a clinical scientist in a small hospital, you are in discussions with the clinical multidisciplinary team about the feasibility of introducing a new laboratory test to measure ‘analyte X’ in the biochemistry laboratory. It is hoped the introduction of this test will help reduce the number of patients being referred for unnecessary invasive

investigations for disease Y. Critically discuss the considerations for introducing this test. (NB Analyte X = small protein. keep the analyst and disease Unknown and just discuss the analytic method.

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You might want to consider/critically discuss the following in your assignment:
• Clinical & analytical requirements for the proposed test.
• Possible methods that could be employed to measure X.
• Practice considerations for implementing such a test.
• Word count 2000-2500 words
discuss: principle- cost- time – advantages and disadvantages each procedure- also discuss accuracy and sensitivity – sample preparation – pre and analytic & post-analytic considerations.
Spectophomtery and Photometry, Turbidity and Nephelometry, different type of ELISA
Atomic Absorption Spectrophotometer and Flame Photometry
Immunoassay, Fluorometry, and Chemiluminescence.
Electrochemistry and Osmometry

2h ·

1. Use original scientific research article papers and do not use commercial websites (such as Google).
2. Include the references used within the text (as numbers in the bracket ( ), in the order, it is appearing (Harvard style) and full references (in the reference list) at the end of the assignment (not included in the word count or a number of pages).

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